Endocrine Abstracts

Background: Osteoporosis is a systemic skeletal disease characterized by low bone mass, microarchitectural deterioration of bone tissue, and the consequence of an increased fracture risk. The term “artificial intelligence (AI)” denotes a field in computer science which enables computers to simulate different aspects of human intelligence, such as natural language understanding, pattern recognition or data driven learning. Machine Learning is a subset of AI, and withi...

Background: The myocardium is a target tissue for vitamin D, that was shown to exert several effects on cardiac contractility and calcium homeostasis. We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD).Methods and Results: We measured 25-hydroxyvitamin D [25(OH)D] in 3299 Caucasian patients that were all routinely referred to coronary angiography at baseline (1997–2000). 25(OH)...

BackgroundMetformin is a widely used and effective agent in type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome (PCOS). Yet, the mechanisms of action and the occurrence of side effects (e.g. abdominal bloating and pain), are still poorly understood. Since organic cation transporters (OCTs) are responsible for the hepatic and renal transport of metformin, we investigated a series of short nucleotide polymorphisms (SNPs) in the OCT genes in PCOS ...